Yogurt Containing Lactobacillus gasseri Mitigates Aspirin-Induced Small Bowel Injuries: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
| Autor: | Akira Tamura, Takayoshi Suzuki, Yukio Asami, Jin Imai, Toshihiro Ohtsu, Jun Aoki, Jun Nakamura, Aya Masui, Ozawa Hideki, Hirohiko Nakae, Masashi Matsushima, Shingo Tsuda, Atsushi Takagi, Tetsuya Mine, Hirokazu Shiozawa |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Aspirin biology business.industry Gastroenterology Placebo-controlled study Lactobacillus gasseri biology.organism_classification Surgery Double blind 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine 030211 gastroenterology & hepatology business Beneficial effects medicine.drug |
| Zdroj: | Digestion. 95:49-54 |
| ISSN: | 1421-9867 0012-2823 |
| Popis: | Background: Although there is evidence about the beneficial effects of probiotics, their effects on aspirin-induced small bowel injuries have not been well examined. We evaluated the effects of the probiotic Lactobacillus gasseri OLL2716 (LG) on aspirin-induced small intestinal lesions, such as ulcers, erosions, reddened lesions, and bleeding. Summary: This study enrolled 64 patients who received aspirin for more than 1 month and provided written informed consent to be part of the study. The patients received 112 ml of yogurt containing LG or placebo twice daily for 6 weeks. Small bowel injuries were evaluated by capsule endoscopy before and after consuming the yogurt. The effect of LG on patient symptoms was also assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG) and Gastrointestinal Symptom Rating Scale (GSRS) questionnaires before and after 6 weeks of treatment. There was no significant difference in any baseline characteristics and the number of small bowel mucosal breaks between the 2 groups. In contrast with the placebo group, the LG group had significantly fewer small bowel mucosal breaks and reddened lesions after 6 weeks (p < 0.01). The FSSG and GSRS scores were also significantly improved in the LG group but not in the placebo group. Key Messages: This double-blind, placebo-controlled study found that LG may be useful in reducing aspirin-induced small bowel injuries and in mitigating gastrointestinal symptoms. |
| Databáze: | OpenAIRE |
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