Activated charcoal alone or after gastric lavage: a simulated large paracetamol intoxication
| Autor: | Helle Riis Angelo, D. Levin, Lotte Christine Groth Hoegberg, J. P. Kampmann, A. B. Christophersen |
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| Rok vydání: | 2002 |
| Předmět: |
inorganic chemicals
Pharmacology business.industry medicine.medical_treatment food and beverages respiratory system equipment and supplies Drug overdose medicine.disease Gastric lavage Acetaminophen carbohydrates (lipids) Activated charcoal visual_art Anesthesia Toxicity medicine visual_art.visual_art_medium Ingestion Pharmacology (medical) Charcoal business medicine.drug Activated carbon |
| Zdroj: | British Journal of Clinical Pharmacology. 53:312-317 |
| ISSN: | 0306-5251 |
| DOI: | 10.1046/j.0306-5251.2001.01568.x |
| Popis: | Aims Activated charcoal is now being recommended for patients who have ingested potentially toxic amounts of a poison, where the ingested substance adsorbs to charcoal. Combination therapy with gastric lavage and activated charcoal is widely used, although clinical studies to date have not provided evidence of additional efficacy compared with the use of activated charcoal alone. There are also doubts regarding the efficacy of activated charcoal, when administered more than 1 h after the overdose. The aim of this study was to examine if there was a difference in the effect of the two interventions 1 h post ingestion, and to determine if activated charcoal was effective in reducing the systemic absorption of a drug, when administered 2 h post ingestion. |
| Databáze: | OpenAIRE |
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