Heavy-Metal-Free Reduction Methodology for Large-Scale Synthesis Applicable to Heterocyclic and Arylhydrazines

Autor:	Mariano Stivanello, Samuela Zambelli Franz, Chiara Bezze, Timothy Norris
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Green chemistry Aqueous solution Scale (ratio) Organic Chemistry Inorganic chemistry Hydrazine Salt (chemistry) Reduction (complexity) chemistry.chemical_compound chemistry Metal free Anhydrous Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 13:354-357
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op8002163
Popis:	A green chemistry methodology that uses a heavy-metal-free reduction in aqueous medium is described to produce 5-hydrazinoquinoline [1-(quinolin-5-yl)hydrazine] (6a) as the anhydrous dihydrochloride salt at large scale. The process is entirely aqueous and utilizes l-ascorbic acid to reduce the diazonium salt (2a) derived from 5-aminoquinoline [quinolin-5-amine] (1a).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e86e5841c9dfc20d8d375c4da73eef6d https://doi.org/10.1021/op8002163 Zobrazit plný text záznamu