| Autor: |
Olabisi O. Ogunrinola, Babajide O. Elemo, O. B. Adu, O. O. Fajana, Gbemisola Morounke Saibu, O. B. Falua, G. A. Adeyemo |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Asian Journal of Biochemistry, Genetics and Molecular Biology. :6-14 |
| ISSN: |
2582-3698 |
| DOI: |
10.9734/ajbgmb/2021/v7i430179 |
| Popis: |
This work demonstrated the immunological and antioxidant activities of Thaumatococcus daniellii leaf extracts and their potential as the pharmaceutical factor for the treatment of some pathological disorders such as cancer, leucopenia, cells inflammation, dietary, atherosclerosis, neurodegenerative disease and other immunological and oxidative stress disorders.36 albino rats of average weight 140 ± 5 g were randomly grouped into 6 with six rats per group. The rats in group A (positive control) received only 0.1% DMSO. The rats in the negative control (group B) received pyrogallol (immunosuppressor) + 0.1% DMSO for 7 days and challenged with 0.1ml Sheep Red Blood Cell (SRBC). The test groups (C to F) also received pyrogallol + 0.1% DMSO for 7 days and were also challenged with SRBC for a period of 72hours after which they were treated with High and Low doses of either petroleum ether or water extracts of Thaumatococcus danielii for 21days. The assessment of immunomodulatory activity was carried out using Carbon Clearance Test. Haematological/ immunological parameters, Spleen and Plasma antioxidant parameters like Catalase (CAT), Superoxide dismutase (SOD), Glutathione Peroxidase (GPX) Activities, Lipid Peroxidation (LPO) and Malonaldehyde (MDA) concentrations were also determined. Result unveiled a significant (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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