Protective effects of ginseng extracts and common anti-aggregant drugs on ischaemia-reperfusion injury : cardiovascular topics
| Autor: | Suleyman Yazici, Oguz Karahan, Orkut Güçlü, Celal Yavuz, Sinan Demirtaş, Ahmet Caliskan, Orhan Tezcan |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty biology business.industry Paraoxonase Kidney metabolism General Medicine Pharmacology Clopidogrel Malondialdehyde PON1 law.invention chemistry.chemical_compound Ginseng chemistry law Ginsenoside medicine biology.protein Cardiology and Cardiovascular Medicine Phytotherapy business medicine.drug |
| Zdroj: | Cardiovascular Journal Of Africa. 26:222-226 |
| ISSN: | 1680-0745 1995-1892 |
| Popis: | Objective : Ginseng is a traditional herbal medicinal product widely used for various types of diseases because of its cellular protective effects. Possible protective effects of ginseng were investigated in blood, cardiac and renal tissue samples and compared with common anti-aggregant agents in an animal ischaemia-reperfusion (I/R) model. Methods : Twenty rats were equally divided into four different groups as follows: control group (I/R-induced group without drug use), group I (acetylsalicylic acid-administered group), group II (clopidogrel bisulfate-administered group), group III (ginsenoside Rb1-administered group). For the groups assigned to a medication, peripheral I/R was induced by clamping the femoral artery one week after initiation of the specified medication. After reperfusion was initiated, cardiac and renal tissues and blood samples were obtained from each rat with subsequent analysis of nitrogen oxide (NOx), malondialdehyde (MDA), paraoxonase 1 (PON1) and prolidase. Results : NOx levels were similar in each group. Significant decrements were observed in serum PON1 levels in each group when compared with the control (p < 0.05). Serum MDA levels were significantly lower in groups II and III (p < 0.05). Ameliorated renal prolidase levels were detected in study groups (p < 0.05) and recovered cardiac prolidase levels were obtained in groups II and III (p < 0.05). Conclusion : These findings indicate that ginseng extracts may have a potential beneficial effect in I/R injury. However, more comprehensive studies are required to clarify the hypothetical cardiac, renal and systemic protective effects in reperfusion-induced oxidative damage. |
| Databáze: | OpenAIRE |
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