Straightforward Synthesis of Allylated Keto Esters: The Palladium-Catalysed Haloketone Alkoxycarbonylation/ Allylation Domino Reaction

Autor:	Steven Giboulot, Yves Castanet, Benoit Wahl, Mathieu Sauthier, Giovanni Poli, André Mortreux, Frédéric Liron
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Ketone Xantphos organic chemicals food and beverages General Chemistry Alkylation Haloketone Tsuji–Trost reaction chemistry.chemical_compound chemistry Cascade reaction Nucleophile Organic chemistry Carbonylation
Zdroj:	Advanced Synthesis & Catalysis. 354:1077-1083
ISSN:	1615-4150
Popis:	The palladium-catalysed α-chloro ketone methoxycarbonylation and allylic alkylation reactions can be efficiently combined to provide a new catalytic domino reaction. The first, carbonylative, step generates the β-keto ester, which acts as the nucleophile in a subsequent allylation step. The use of allyl phenates in combination with Xantphos ligand are the key features allowing one to obtain the allylated β-keto esters in good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e84dedc38abff6932d00dc1820519019 https://doi.org/10.1002/adsc.201100848 Zobrazit plný text záznamu Plný text