Reactions of Ethyl 5-Methyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylate with Selected Bases
| Autor: | L. M. Pevzner, Yu. O. Remizov, Mikhail L. Petrov |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Potassium Hydrazine chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Potassium carbonate chemistry.chemical_compound chemistry Morpholine Hydrate Derivative (chemistry) Tetrahydrofuran Methyl iodide |
| Zdroj: | Russian Journal of General Chemistry. 89:2147-2150 |
| ISSN: | 1608-3350 1070-3632 |
| DOI: | 10.1134/s1070363219100256 |
| Popis: | The reactions of 5-methyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylic acid ethyl ester with some bases have been studied. The opening of 1,2,3-thiadiazole ring under the action of potassium tert-butylate in tetrahydrofuran in the presence of methyl iodide has led to the corresponding 4-methylsulfanylethynylfuran derivative. Under the action of potassium carbonate in DMF with an excess of primary amines or morpholine, the starting thiadiazole has formed the corresponding thioamides of furylacetic acid. The reaction of ethyl 5-methyl-4-(1,2,3-thiadiazol-4-yl)furan-2-carboxylate with hydrazine hydrate has led to hydrazinolysis of the ester group without cleavage of the 1,2,3-thiadiazole ring. |
| Databáze: | OpenAIRE |
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