Peripheral Foxp3+ regulatory T cell development in response to self-peptides (65.2)
| Autor: | Katherine Weissler, Felipe Bedoya, Elizabeth Kropf, Victoria Garcia, Andrew Caton |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 188:65.2-65.2 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.188.supp.65.2 |
| Popis: | It is generally accepted that developing thymocytes can become Foxp3+ regulatory T cells (Tregs) through recognition of self-antigens during thymic selection. Tregs can also develop from conventional CD4+ T cells responding to exogenously administered peptides (including food antigens) in vivo, and via TGF-β signaling during activation in vitro, but the processes by which Treg induction may occur in response to self-peptides in the periphery remain unclear. We are examining this question by transferring conventional CD4+CD25-Foxp3- T cells specific for influenza virus hemagglutinin (HA) into mice that express varying amounts of the HA molecule as a self-antigen (HA Tg mice). We find that conventional CD4+ T cells can convert into Foxp3+ Tregs upon recognition of a self-antigen in the lymph nodes and spleens, and that accumulation of HA-specific Tregs is greater in mice expressing HA at lower levels than it is in mice expressing relatively higher levels of HA. Conversion occurs most efficiently at sites draining mucosal surfaces, in agreement with published studies demonstrating the existence of specialized subsets of dendritic cells at these locations that promote Treg induction. We also find that the extent of Treg induction in response to a self-antigen is essentially unaffected by acute viral infection. These studies are defining parameters that determine the ability of self-peptides to induce the formation of Foxp3+ Tregs in the periphery. |
| Databáze: | OpenAIRE |
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