The phospholipase A2 activity of peroxiredoxin 6 promotes cancer cell death induced by tumor necrosis factor alpha in hepatocellular carcinoma
| Autor: | Xuyong Wei, Haiyang Xie, Runzhou Zhuang, Yang-Bo Zhu, Lin Zhou, Xuanyu Zhang, Shusen Zheng, Zeng-Lei He, Cheng Zhong, Di Lu, Chao Wang, Qiang Wei, Xiao Xu, Jianguo Wang |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cancer Research Messenger RNA biology medicine.medical_treatment medicine.disease_cause medicine.disease digestive system diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Phospholipase A2 Apoptosis 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer cell Immunology Cancer research medicine biology.protein Tumor necrosis factor alpha Hepatectomy Carcinogenesis Molecular Biology |
| Zdroj: | Molecular Carcinogenesis. 55:1299-1308 |
| ISSN: | 0899-1987 |
| DOI: | 10.1002/mc.22371 |
| Popis: | In this study, we used proteomic profiling to compare hepatocellular carcinoma (HCC) and peri-tumoral tissues to identify potential tumor markers of HCC. We identified eight differentially expressed proteins (>3-fold), including Peroxiredoxin 6 (PRDX6). PRDX6 is a bifunctional enzyme with both peroxidase and calcium-independent phospholipase A2 (iPLA2) activity. We found that peri-tumoral tissues expressed higher levels of PRDX6 mRNA (n = 59, P = 0.018) and protein (n = 265, P |
| Databáze: | OpenAIRE |
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