Feasibility study of paper-based surface enhanced Raman spectroscopy of tear fluids for onsite therapeutic drug monitoring
| Autor: | Yuko Ohno, Eiichi Tamiya, Daiki Mita, Kenji Yamada, Michiko Kido, Yoshiaki Sakurai, Toshiaki Nagakura, Yoshinori Yamaguchi, Moe Yokoyama, Takahiro Nishimura |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
medicine.diagnostic_test Scanning electron microscope technology industry and agriculture Nanotechnology Substrate (electronics) Paper based Surface-enhanced Raman spectroscopy symbols.namesake Adsorption Specimen collection Therapeutic drug monitoring medicine symbols Raman spectroscopy |
| Zdroj: | 2014 World Automation Congress (WAC). |
| DOI: | 10.1109/wac.2014.6936005 |
| Popis: | This paper discuss drug concentration measurement based on Raman spectroscopy of tear fluids with paper substrates for on-site therapeutic drug monitoring (TDM). We focus on tear fluids as alternative specimens to blood for minimally-invasive TDM. By using paper substrates, specimen collection and measurement based on surface enhanced Raman spectroscopy will be performed easily and inexpensively. In experiment, we fabricated paper-based substrate for surface enhanced Raman spectroscopy (SERS) of tear fluids and evaluated its surface. Scanning electron microscope images of them showed that gold nano-rods were adsorbed on the surface uniformly. This result implies that analysis of tear fluids with paper substrates would be realized with high sensitivity by SERS. |
| Databáze: | OpenAIRE |
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