Morphological analysis of protease treatment of damaged nerves
| Autor: | G. M. Insezharova, O. S. Sotnikov, M. Yastrembski, V. G. Lukashin |
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| Rok vydání: | 1995 |
| Předmět: |
Wallerian degeneration
Protease medicine.diagnostic_test Proteolysis medicine.medical_treatment Regeneration (biology) General Medicine Degeneration (medical) Pronase Anatomy Biology medicine.disease General Biochemistry Genetics and Molecular Biology Myelin medicine.anatomical_structure nervous system Morphological analysis medicine |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 119:425-428 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02445912 |
| Popis: | Intravitam phase-contrast microscopy of individual isolated myelin fibers of rabbit tibial nerves shows that 40-min treatment with 0.2% pronase solution is harmless to intact myelin fibers. In injured nerves such treatment causes sharply expressed proteolysis and a rapid process of wallerian degeneration with ruptures of the axial cylinders and the formation of degeneration ovoids. The findings prove the feasibility and desirability of early primary protease treatment of nerve wounds. |
| Databáze: | OpenAIRE |
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