ChemInform Abstract: Copper-Catalyzed Intermolecular Carboetherification of Unactivated Alkenes by Alkyl Nitriles and Alcohols

Autor:	Claire Chatalova-Sazepin, Qian Wang, Jieping Zhu, Glenn M. Sammis
Rok vydání:	2015
Předmět:	chemistry.chemical_classification chemistry Radical clock Intermolecular force Copper catalyzed General Medicine Medicinal chemistry Alkyl Quaternary carbon
Zdroj:	ChemInform. 46
ISSN:	0931-7597
DOI:	10.1002/chin.201536062
Popis:	A three-component carboetherification of unactivated alkenes has been developed allowing the rapid building of complexity from simple starting materials. A wide range of α-substituted styrenes underwent smooth reactions with unactivated alkyl nitriles and alcohols to afford γ-alkoxy alkyl nitriles with concomitant generation of a quaternary carbon center. A radical clock experiment provided clear-cut evidence that the reaction proceeds through a tertiary alkyl radical intermediate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e8365f87f2951d4dedd2a9731a3333bd https://doi.org/10.1002/chin.201536062 Zobrazit plný text záznamu Plný text