Dynamic Kinetic Resolution of α-Amino Acid Esters in the Presence of Aldehydes

Autor:	Stephan Enthaler, Udo Kragl, Daniel Schichl, Thomas Dr. Riermeier, Wolfgang Holla, Matthias Beller
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Enzyme Chemistry Biocatalysis Yield (chemistry) Organic Chemistry Organic chemistry Ester hydrolysis Physical and Theoretical Chemistry Racemization Amino acid Kinetic resolution Catalysis
Zdroj:	European Journal of Organic Chemistry. 2008:3506-3512
ISSN:	1099-0690 1434-193X
Popis:	A convenient procedure for the racemization of α-amino acid esters in the presence of catalytic amounts of salicylaldehydes is described. The combination of this racemization protocol with lipase-catalyzed ester hydrolysis allows successful dynamic kinetic resolution of various α-amino acid esters. The corresponding α-amino acids are obtained in high yield and optical purity.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Databáze:	OpenAIRE
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