Rapid Assessment of Organophosphate-Induced Cholinesterase Depression: A Comparison of Laboratory and Field Kit Methods to Detect Human Exposure to Organophosphates
| Autor: | Dawn Tharr, Elizabeth L. Atkins, Carol H. Rubins, David R. Olsoni, Richard J. Jackson |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Medical surveillance
medicine.medical_specialty Venipuncture biology business.industry Organophosphate Public Health Environmental and Occupational Health Rapid assessment Toxicology chemistry.chemical_compound chemistry Human exposure Emergency medicine biology.protein Parathion methyl Medicine business Depression (differential diagnoses) Cholinesterase |
| Zdroj: | Applied Occupational and Environmental Hygiene. 13:265-268 |
| ISSN: | 1521-0898 1047-322X |
| DOI: | 10.1080/1047322x.1998.10390080 |
| Popis: | Summary The National Institute for Occupational Safety and Health (NIOSH) recommends monitoring blood cholinesterase levels among workers who handle pesticides as a means of detecting exposure to organophosphate compounds that inhibit these enzymes. Traditionally this medical surveillance involves collecting venipuncture blood samples that are sent to a laboratory for analysis. Because this can be a time-consuming process, and because workers often object to serial venipuncture sampling, rapid-assay technology is being developed. To test the reliability of an on-site finger-stick system, we tested 97 workers for cholinesterase inhibition using the standard venipuncture method and using a spectrophotometric field kit. We also assessed exposure by analyzing urine samples for para-nitrophenol (p-NP). The workers, who were cleaning private residences contaminated with the organophosphate methyl parathion, were tested before starting work and then repeatedly over a 7-week period. We compared results of the two... |
| Databáze: | OpenAIRE |
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