The Effects of the Lipid Complex of Extract from the Marine Red Alga Ahnfeltia tobuchiensis (Kanno et Matsubara) Makienko on the Biochemical Parameters of Blood Plasma and Erythrocyte Membranes during Experimental Stress Exposure
| Autor: | V. G. Sprygin, N. F. Kushnerova, S. E. Fomenko, T. V. Momot |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
biology Cholesterol 010604 marine biology & hydrobiology Ahnfeltia Phospholipid Blood lipids 04 agricultural and veterinary sciences Essentiale Aquatic Science Oceanography biology.organism_classification 01 natural sciences chemistry.chemical_compound Membrane Biochemistry chemistry Blood plasma 040102 fisheries 0401 agriculture forestry and fisheries lipids (amino acids peptides and proteins) Lipoprotein |
| Zdroj: | Russian Journal of Marine Biology. 46:277-283 |
| ISSN: | 1608-3377 1063-0740 |
| DOI: | 10.1134/s1063074020040057 |
| Popis: | The present study considers effects of a lipid complex isolated from the aqueous–ethanol (70%) extract from the marine red alga Ahnfeltia tobuchiensis and effects of the Essentiale commercial preparation on the biochemical parameters of blood plasma and erythrocyte membranes of mice exposed to experimental stress (suspension by the scruff of the neck). The pharmacological effect of the lipid complex from A. tobuchiensis is manifested as elimination of dyslipidemia and hypercholesterolemia accompanied by a reduction in the levels of total lipids and low-density lipoproteins, an increase in the level of high-density lipoproteins in plasma, and normalization of the cholesterol/phospholipid ratio and the phospholipid composition of erythrocyte membranes. The Ahnfeltia extract was not inferior to the Essentiale reference preparation in terms of effectiveness and was even superior in the potential to restore the blood lipid composition and the phospholipid fraction ratio in erythrocyte membranes. The pharmacological effect of the lipid complex from Ahnfeltia is determined by the action of its phospholipid fractions and polyunsaturated n-6 and n-3 fatty acids, which contribute to the utilization of cholesterol from membranes and the enhancement of the lipoprotein ratio towards increase in high-density lipoproteins and are also involved in erythrocyte membrane repair. |
| Databáze: | OpenAIRE |
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