Impact of bacterial autoregulatory molecules (homoserine lactones and alkylhydroxybenzenes) on the oxidative metabolism of the cell effectors of natural immunity
| Autor: | Dmitry G. Deryabin, V. A. Chereshnev, Galina I. El-Registan, T. G. Sviridova |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Innate immune system Effector Phagocytosis Neutrophile Cell Homoserine food and beverages Biology Applied Microbiology and Biotechnology Microbiology law.invention chemistry.chemical_compound medicine.anatomical_structure Biochemistry chemistry law medicine Chemiluminescence |
| Zdroj: | Microbiology. 82:133-141 |
| ISSN: | 1608-3237 0026-2617 |
| DOI: | 10.1134/s0026261713020045 |
| Popis: | We investigated the impact of bacterial regulators homoserine lactones (HSLs) and alkylhydroxybenzenes (AHBs) (which are present in human fluids at pico- and nanomolar concentrations) on neutrophile oxidative metabolism. The HSL and AHB effects were determined using a test based on induced luminol-dependent chemoluminescence of neutrophiles in human peripheral blood. In this test, neutrophiles were preincubated with chemical analogs of bacterial autoregulators with different lengths of the hydrocarbon radical, such as HSL · HCl, C6- and C12-HSL, and C1-, C6-, and C12-AHB. We revealed that they suppressed the chemoluminescence and, accordingly, the oxidative metabolism of neutrophiles. This effect was more significant with HSLs than with AHBs. Within each of the two groups, the effect increased with an increase in the length of the hydrocarbon chain of the homologues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink