PD44-08 NOVEL DUAL TARGETING AKR1C3 AND AR/AR VARIANTS INHIBITS ANDROGEN SIGNALING AND OVERCOMES RESISTANCE TO ANTIANDROGEN TREATMENT

Autor:	Shu Ning, Pui-Kai Li, Allen C. Gao, Wei Lou, Jinge Zhao, Cameron M. Armstrong, Christopher P. Evans
Rok vydání:	2021
Předmět:	Prostate cancer Dual targeting medicine.drug_class business.industry Antiandrogen Treatment Urology medicine Cancer research Androgen business medicine.disease
Zdroj:	Journal of Urology. 206
ISSN:	1527-3792 0022-5347
DOI:	10.1097/ju.0000000000002058.08
Popis:	INTRODUCTION AND OBJECTIVE:AR/AR-V7 and AKR1C3 play key roles in prostate cancer progression and drive resistance to current therapies. Thus far, there are no clinically available therapies to spec...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e8298f1e498c5a0f1aa7833fc4db715a https://doi.org/10.1097/ju.0000000000002058.08 Zobrazit plný text záznamu