Novel asymmetric dealkoxycarbonylation of 3-oxo-8-azabicyclo[3.2.1]-octane-2,4-dicar☐ylates using porcine liver esterase: A new route to (−)-anhydroecgonine methyl ester

Autor:	Manabu Node, Takahiro Katoh, Kiyoharu Nishide, Daisaku Nakamura, Soichi Nakamura
Rok vydání:	1999
Předmět:	Hydrolysis chemistry.chemical_compound Chemistry Stereochemistry Porcine liver Organic Chemistry Drug Discovery Enantioselective synthesis Esterase A Anhydroecgonine methyl ester Enantiomeric excess Biochemistry Octane
Zdroj:	Tetrahedron Letters. 40:5357-5360
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(99)00976-4
Popis:	The porcine liver esterase-catalyzed dealkoxycarbonylation of 8-benzyl-3-oxo-8-azabicyclo[3.2.1]octane-2,4-dicar☐ylates (4) was found to give high enantiomeric excess of the desymmetrized keto ester (5). This novel dealkoxyl-carbonylation opened a new route to the asymmetric synthesis of (1R)-cocaine related radiopharmaceuticals such as (1R)-β-CIT, for diagnosis of Parkinson's disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e81df706ca4a3a193bb2e0bc145330e1 https://doi.org/10.1016/s0040-4039(99)00976-4 Zobrazit plný text záznamu Full Text from ScienceDirect