Inverse Association Between Fatty Liver at Baseline Ultrasonography and Remission of Type 2 Diabetes Over a 2-Year Follow-up Period
| Autor: | Akio Katanuma, Tsukasa Kamitani, Shinichi Tauchi, Nagisa Hanawa, Yosuke Yamamoto, Yoshifumi Saisho, Hajime Yamazaki, Shunichi Fukuhara, Mitsuru Dohke, Jui Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Hepatology business.industry medicine.medical_treatment Fatty liver Gastroenterology Odds ratio Type 2 diabetes medicine.disease Single Center 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Diabetes mellitus medicine 030211 gastroenterology & hepatology Hemodialysis Steatosis business Body mass index |
| Zdroj: | Clinical Gastroenterology and Hepatology. 19:556-564.e5 |
| ISSN: | 1542-3565 |
| DOI: | 10.1016/j.cgh.2020.06.032 |
| Popis: | Background & Aims Improvement of fatty liver may be required for remission of type-2 diabetes. However, there is no longitudinal evidence on whether fatty liver reduces the chances for remission of type-2 diabetes. We investigated the association between fatty liver and remission of type-2 diabetes (the primary analysis), and also the association between improvement of fatty liver and remission of type-2 diabetes (the secondary analysis). Methods We collected data from 66961 people who underwent screening for type-2 diabetes from 2008 through 2016 at a single center in Japan. The primary analysis included 2567 patients with type-2 diabetes without chronic renal failure or a history of hemodialysis who underwent ultrasonography to detect fatty liver, all of whom had follow-up testing, including blood testing, for a median 24.5 months after the baseline ultrasonography. The secondary analysis included 1833 participants with fatty liver at baseline who underwent a second ultrasonography, and participants who had fatty liver at baseline but not at the second visit were considered to have had improvement of fatty liver. Remission of type-2 diabetes was defined as a fasting plasma glucose level below 126 mg/dL and an HbA1c level below 6.5% for more than 6 months without anti-diabetic drugs. Odds ratios (ORs) of remission of type-2 diabetes were estimated using logistic-regression models. Results A lower proportion of patients who had fatty liver detected by ultrasonography at baseline (8.7%, 167/1910) had remission of type-2 diabetes during the follow-up period than patients without fatty liver (13.1%, 86/657). Fatty liver at baseline was associated with a lower odds of remission of type-2 diabetes (multivariable-adjusted OR, 0.51; 95% CI, 0.37–0.72). A higher proportion of patients who had improvement of fatty liver had remission of type-2 diabetes (21.1%, 32/152) than patients with no improvement of fatty liver (7.7%, 129/1681). Improvement of fatty liver was associated with a higher odds of remission of type-2 diabetes (multivariable-adjusted OR, 3.08; 95% CI, 1.94–4.88). Conclusions Over a follow-up period of approximate 2 years, remission of type-2 diabetes was less common in people with fatty liver detected by ultrasonography, and improvement of fatty liver was independently associated with type-2 diabetes remission. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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