Facile Synthesis of Zinc Oxide Nanoparticles Using Novel Areca catechu Leaves Extract and Their In Vitro Antidiabetic and Anticancer Studies
| Autor: | U. R. Shwetha, Virupaxappa S. Betageri, M. S. Latha, C. R. Rajith Kumar, M. S. Kiran |
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| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Reducing agent Chemistry technology industry and agriculture Nanoparticle chemistry.chemical_element 02 engineering and technology Zinc Catechu 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences In vitro Yeast 0104 chemical sciences Materials Chemistry Composition (visual arts) Crystallite 0210 nano-technology health care economics and organizations Nuclear chemistry |
| Zdroj: | Journal of Inorganic and Organometallic Polymers and Materials. 30:4876-4883 |
| ISSN: | 1574-1451 1574-1443 |
| DOI: | 10.1007/s10904-020-01575-w |
| Popis: | In this work, zinc oxide nanoparticles (ZnO NPs) have been prepared using Areca catechu leaves extract as a bio reducing agent through solution combustion synthesis. Several analytical techniques namely, XRD, UV–Vis spectroscopy, SEM with EDS and HR-TEM were used to validate the prepared ZnO NPs. XRD analysis revealed that synthesised NPs are crystalline in nature with average crystallite size of 29 nm. From the SEM and HR-TEM the morphology of prepared NPs exhibited the agglomeration with spherical shape and composition of elements confirmed by EDS respectively. Further, the prepared ZnO NPs tested for antidiabetic properties with yeast as model comparing to standard drug (Metronidazole). It is observed that decrease in uptake by yeast cell may be attributed to antidiabetic activity of ZnO NPs at higher concentrations. In addition, cytotoxic activity on the cell line of the Michigan Cancer Foundation-7 (MCF-7) has shown that the prepared ZnO NPs have substantial potential anticancer activity with a concentration of 52.64 μg/ml (IC50 value). |
| Databáze: | OpenAIRE |
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