HBF4·OEt2 as a versatile reagent for the Hosomi–Sakurai allylation and Prins cyclization: one-pot synthesis of symmetrical 4-fluorotetrahydropyrans

Autor:	B. Anusha, J. S. Yadav, V. V. Bhadra Reddy, U.V. Subba Reddy, B. V. Subba Reddy
Rok vydání:	2010
Předmět:	Tandem Chemistry Reagent Organic Chemistry Drug Discovery One-pot synthesis Organic chemistry Single step Prins reaction Biochemistry
Zdroj:	Tetrahedron Letters. 51:2872-2874
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2010.03.082
Popis:	The synthesis of symmetrical 2,6-disubstituted 4-fluorotetrahydropyran derivatives has been achieved using HBF4·OEt2 via a tandem allylation and Prins cyclization. This is a highly efficient and diastereoselective approach for the preparation of 4-fluorotetrahydropyrans in a single step. The use of readily available and easy to handle reagent HBF4·OEt2 makes this method simple, convenient and practical.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e802a54f1d2c6e6d9a0ccb7ba4a1bde2 https://doi.org/10.1016/j.tetlet.2010.03.082 Zobrazit plný text záznamu Full Text from ScienceDirect