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Curcuma thorelii Gagnep. and Curcuma cotuana Luu, Škorni?k. & H.?.Tr?n are the rare species only found in Southeast Asia. The present study was the first to explore the chemical compositions and antibacterial effects of the whole plant acetone extracts of these 2 species. Altogether 41 and 31 compounds have been identified in C. thorelii and C. cotuana extracts by gas chromatography/mass spectrometry. Accordingly, the C. thorelii extract contained (E)-labda-8(17),12-diene-15,16-dial (33.37%), vitamin E (12.33%), phytol (9.83%) as the major compounds while C. cotuana extract contained predominantly (E)-labda-8(17),12-diene-15,16-dial (14.58%), n-hexadecanoic acid (10.96%), 3,7,11,15-tetramethylhexadec-2-en-1-yl acetate (8.13%), ?-sitosterol (7.97%). In addition, results from disc diffusion assay have shown that C. thorelii acetone extract had inhibitory effects on 5 out of 10 pathogenic bacterial strains such as Bacillus cereus (ATCC 11778), Listeria monocytogenes (ATCC 19111), Staphylococcus aureus (ATCC 25923), S. aureus (ATCC 29213) and S. saprophyticus (BAA750) while C. cotuana acetone extract was found to be effective only against B. cereus. The obtained results showed that the acetone extracts of C. thorelii and C. cotuana possessed several valuable bioactive compounds as well as promising antibacterial activity, which place a good foundation for future pharmaceutical product development. |
