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When certain mutagenic anti-cancer medicines are used for cancer therapy, secondary production of cancer by the medicines themselves is feared. Certain bio-antimutagenic substances may decrease secondary cancer induction without interfering with the effectiveness of the anti-cancer therapies. The bio-antimutagenic effects of cobaltous chloride, gallic acid, taurine and isethionate on the anti-cancer medicines chlorambucil and methotrexate were investigated using the Drosophila melanogaster wing spot test. Cobaltous chloride reduced the mutagenicity of methotrexate, but not chlorambucil. Gallic acid reduced the mutagenicity of both medicines. Taurine and isethionate also reduced the mutagenicity of methotrexate. |
