Thyroid Peroxidase: Studies on Auto-Antibody Recognition, Gene Expression and Secondary Structure Prediction
| Autor: | J. P. Banga, Nan D. Doble, R. W. S. Tomlinson, K. S. Collison, P. S. Barnett, Daruka Mahadevan, Alan McGregor |
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| Rok vydání: | 1990 |
| Předmět: |
endocrine system
medicine.medical_specialty education.field_of_study biology medicine.medical_treatment Thyroid Population Autoantibody Immune system Endocrinology medicine.anatomical_structure Thyroid peroxidase Internal medicine biology.protein medicine Thyroglobulin Antibody education Intracellular |
| Zdroj: | The Molecular Biology of Autoimmune Disease ISBN: 9783642751356 |
| DOI: | 10.1007/978-3-642-75133-2_36 |
| Popis: | The spectrum of autoimmune thyroid diseases (AITD) are common, being seen in 2–4% of the population in areas of adequate dietary iodine intake and are increasing well characterised clinically and immunologically (Weetman et al 1984). The recognition of the likely immunological basis of AITD dates back to 1956 with the observations of Rose and Witebsky in animal models and Roitt and Doniach in man on antibody activity against thyroglobulin (TG). The subsequent demonstration of autoantibody activity against thyroid cell cytoplasmic constituents (Roitt et al 1964), despite the frequency with which this autoantibody activity is associated with AITD, left unresolved the question of how an intracellular determinant might be accessible to the immune system and therefore questioned the clinical relevance of these autoantibodies. Attempts to characterise and localise the relevant auto-antigen were limited to its recognition as the thyroid “microsomal” auto-antigen (TMA) and as a constituent of thyroid exocytotic vesicles involved in the transfer of TG from the cell to its site of storage in the central colloid space of thyroid follicles. |
| Databáze: | OpenAIRE |
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