| Popis: |
Publisher Summary This chapter discusses the neuroendocrine––ontogenetic model of aging and the ways of its realization. The work on the theories of aging should ultimately be aimed at the elimination of the diseases coupled with the mechanism of aging, to slowing down of the aging process, and broadening of the human lifespan. There are two tendencies in treating the causes of the development of diseases that can be readily traced. In one of them, the main emphasis is made on the external factors such as trauma, overnutrition and undernutrition, pathogenic microorganisms, viruses, chemical and physical carcinogens, stress, and so on. The second model of medicine deals with inborn genetic causes of the development of the diseases or of the predisposition to their development. Some considerations are presented and aimed to find the link between the stochastic processes of aging based on the accumulation of damage in cellular and subcellular structures and, conversely, the orderly processes connected with the mechanisms of the development of an organism. The main consequences of the ontogenetic model are in accordance with this model; the shifting or age-dependent norm assumed at present is misleading, because it is not the norm that it reflects, but the degree of the deviation from the norm of people of different ages. Stress, overnutrition, obesity excessive illumination, and a number of chemical carcinogens cause the decrease in the sensitivity of the hypothalamus to regulatory signals and/or the increase in the fatty acid metabolism. |
