Studies of trace element involvement in human disease by in vitro activation analysis
| Autor: | William D. Ehmann, D. E. Vance |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Chemistry
Health Toxicology and Mutagenesis Radiochemistry Public Health Environmental and Occupational Health Trace element High resolution Computational biology Pollution nervous system diseases Analytical Chemistry High flux Human disease nervous system Nuclear Energy and Engineering immune system diseases mental disorders Radiology Nuclear Medicine and imaging Neutron activation analysis Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry Articles. 203:429-445 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/bf02041521 |
| Popis: | The technique of neutron activation analysis (NAA) was first demonstrated in papers by Georg Hevesy and Hilde Levi in 1936 and 1938. Applications of NAA to biological tissues did not appear in the literature until approximately a decade later, when analysts obtained access to high flux nuclear fission reactors. NAA studies of trace element imbalances in specific diseases developed rapidly in the 1980s with the availability of affordable high resolution, high efficiency, solid-state gamma-ray detectors. A brief history of NAA as related to trace element analyses of human tissues is presented and recent NAA studies of relationships of elemental imbalances to the etiology or pathogenesis of selected diseases are reviewed. |
| Databáze: | OpenAIRE |
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