Role of Multidrug Resistance Proteins (MRP) in Resistance to Antifolates and Folate Homeostasis

Autor:	G. Jansen, Y. G. Assaraf, D. G. Priest, M. Bunni, M. Kool, I. Kathmann, J. H. Hooijberg, R. J. Scheper, B. A. C. Dijkmans, G. J. Kaspers, G. J. Peters
Rok vydání:	2002
Předmět:	Purine chemistry.chemical_classification biology Cofactor chemistry.chemical_compound chemistry Biochemistry Pyrimidine metabolism Multidrug Resistance Proteins Extracellular medicine biology.protein Methotrexate Amino acid synthesis Homeostasis medicine.drug
Zdroj:	Chemistry and Biology of Pteridines and Folates ISBN: 9781461353171
DOI:	10.1007/978-1-4615-0945-5_108
Popis:	Cellular folate homeostasis is essential to allow continuous use of reduced folate cofactors for a variety of biosynthetic processes including purine and pyrimidine biosynthesis, mitochondrial protein synthesis and amino acid biosynthesis. Beyond this, there is accumulating evidence that the antiproliferative and/or anti-inflammatory effects of methotrexate (MTX) or second/third generation of folate antagonists is dependent on the patients cellular folate status. High intra-/extracellular folate levels may abrogate the efficacy of folate antagonists, while low intra-/extracellular folate levels may play a role in determining toxic effects (1,2).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e7e1c311b149fc56d5160ea6fe23b8fd https://doi.org/10.1007/978-1-4615-0945-5_108 Zobrazit plný text záznamu