Lidocaine-derivative JMF2-1 prevents ovalbumin-induced airway inflammation by regulating the function and survival of T cells

Autor:	Patrícia M.R. e Silva, Marco A. Martins, Magda F. Serra, Bruna de Paula Fonseca e Fonseca, Priscilla C. Olsen, Jorge Carlos Santos da Costa, João P. B. Viola, Francisco Alves Farias-Filho, Tatiana P. T. Ferreira, Renato S.B. Cordeiro
Rok vydání:	2010
Předmět:	Inhalation Lidocaine biology business.industry Immunology Inflammation Pharmacology Ovalbumin medicine.anatomical_structure Mechanism of action medicine biology.protein Immunology and Allergy Bronchoconstriction medicine.symptom Airway business medicine.drug Respiratory tract
Zdroj:	Clinical & Experimental Allergy. 41:250-259
ISSN:	0954-7894
Popis:	Inhalation of the local anaesthetic lidocaine has been suggested to be beneficial for asthmatics, but airway anaesthesia is unpleasant and may exacerbate bronchoconstriction. Our previous study showed that inhalation of the lidocaine analogue JMF2-1 can elicit the anti-inflammatory properties of lidocaine without anaesthesia. This prompted further research on the mechanism of action and putative therapeutic application of JMF2-1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e7e0e6523eb8d55af7d44878f85b30aa https://doi.org/10.1111/j.1365-2222.2010.03580.x Zobrazit plný text záznamu Plný text