| Popis: |
Topical formulations of the antiviral compound trifluorothymidine (TFT) were prepared with different proportions of Azone, propylene glycol (PG), polyethylene glycol (PEG-300) and/or water and evaluated by measuring in vitro diffusion of TFT through excised guinea pig skin. Azone dramatically increased drug flux. With 5% Azone in the vehicle, TFT flux values increased 3–4-fold as the ratio of PG: PEG-300 in the vehicle went from 0:100 to 100:0. In experiments without Azone, the TFT penetration rate in PG was 4-fold greater compared to water and 17-fold greater compared to PEG-300. In summary, Azone and PG both enhanced membrane permeability relative to water and acted synergistically on the penetration of the antiviral compound, while PEG-300 appeared to be less efficient than water as a vehicle. |
