A Case Report of Paraganglioma: A Diagnosis Not to Be Missed
| Autor: | Barmak Gholizadeh, Adel Zeinalpour, Parima Safe, Tayebeh Rostami, M Mozaffar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.diagnostic_test business.industry Umbilicus (mollusc) Physical examination Malignancy medicine.disease Pheochromocytoma Oncology Blurred vision Paraganglioma Medicine Pharmacology (medical) Radiology Nuclear Medicine and imaging Surgery Neoplastic transformation Radiology medicine.symptom business Organ of Zuckerkandl |
| Zdroj: | International Journal of Cancer Management. 13 |
| ISSN: | 2538-497X 2538-4422 |
| DOI: | 10.5812/ijcm.99817 |
| Popis: | Introduction: The autonomic nervous system, a derivative of neural crest cells, may undergo the neoplastic transformation and give rise to paragangliomas, which can arise either at intra-adrenal or extra-adrenal sites, commonly referred to as pheochromocytomas and paragangliomas, respectively. Although indistinguishable at the cellular level and usually identical in clinical manifestation, these two tumors differ in means of malignancy risk, genetic testing, and the probability of detecting an associated neoplasm, highlighting the importance of making a correct diagnosis to prevent additional complications. Case Presentation: We report a 17-year-old female patient presented with sudden blurred vision and palpitation lasting for 1 week. The physical examination revealed tachycardia, hypertension, and a mildly tender mass on the left side of the umbilicus. A spiral abdominal and pelvic computed tomography (CT) scan was performed, which depicted a hypervascular retroperitoneal mass in the left infrarenal region. Mildly-elevated urine metanephrine and normetanephrine levels were suggestive of a paraganglioma (PGL). Iodine-131 metaiodobenzylguanidine (MIBG) scan was also in favor of PGL of the organ of Zuckerkandl. The mass was completely resected and the immunohistochemistry (IHC) study of the specimen confirmed the diagnosis. Conclusions: The diversity of manifestations and rarity of PGL can delay the diagnosis, which may lead to potential complications. This makes it compelling to include PGLs in differential diagnoses in a clinical setting compatible with catecholamine hypersecretion. |
| Databáze: | OpenAIRE |
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