On the inference of ERK signaling dynamics from protein biosensor measurements

Autor:	Shah Md. Toufiqur Rahman, Jason M. Haugh
Rok vydání:	2023
Předmět:	Cell Biology Molecular Biology
Zdroj:	Molecular Biology of the Cell. 34
ISSN:	1939-4586 1059-1524
DOI:	10.1091/mbc.e22-10-0476
Popis:	Live-cell microscopy is used to infer dynamics in single cells. Here, ERK signaling was monitored using four different biosensors in a common cell context. Each responds with unique kinetics, reflecting differences in ERK localization and activity. Mathematical modeling offers an interpretation of the data and may be used to guide biosensor design.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e7cca4b3ac9052d4af83441176029c64 https://doi.org/10.1091/mbc.e22-10-0476 Zobrazit plný text záznamu