Protective Effects of C24 Ceramide From the Seeds of Brassica napus L. Against Ultraviolet B-Induced Photoaging in Normal Human Dermal Fibroblasts
| Autor: | Kyung Suk Bae, Yu M. Kim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Ceramide
Type I Procollagen Photoaging Brassica Plant Science Matrix (biology) 03 medical and health sciences chemistry.chemical_compound Skin photoaging 0302 clinical medicine Drug Discovery medicine 030304 developmental biology Pharmacology 0303 health sciences integumentary system biology food and beverages Ultraviolet b General Medicine medicine.disease biology.organism_classification Molecular biology Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis |
| Zdroj: | Natural Product Communications. 14:1934578X1986064 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x19860644 |
| Popis: | Ultraviolet (UV) radiation induces skin photoaging, which is associated with the elevation of matrix metalloproteinase-1 (MMP-1) and the decrease of collagen. Brassica napus plays a well-known role in the treatment of canola oil through their anti-oxidative and DNA protective properties. However, their skin protective activity toward UVB-induced damage remains unclear. In the present study, we investigated the protective effect of C24 ceramide from B. napus on UVB-irradiated normal human dermal fibroblasts. Our results show that C24 ceramide enhanced NHDFs cell migration. The UVB-induced increase in MMP-1 and decrease in type I procollagen were ameliorated by C24 ceramide treatment. Taken together, our data strongly suggest that C24 ceramide from B. napus could reduce UVB-induced photoaging. |
| Databáze: | OpenAIRE |
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