ChemInform Abstract: Stereoselective Synthesis of β-Amino-α-hydroxy(allyl)phosphinates and an Application to the Synthesis of a Building Block for Phosphinyl Peptides

Autor:	Shiroshi Shibuya, Tsutomu Yokomatsu, Takanori Kusano, Takehiro Yamagishi
Rok vydání:	2010
Předmět:	Hydrolysis Stereochemistry Chemistry Stereoselectivity General Medicine
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
Popis:	Hydrophosphinylation of N,N-dibenzyl-α-amino aldehydes with ethyl allylphosphinate in the presence of (S)-ALB afforded anti-β-amino-a-hydroxy(allyl)phosphinates in high diastereoselectivity. The hydrophosphinylation product was transformed to a potentially useful transition state mimic for hydrolysis of dipeptides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e7c875334dab0e6263580ee97acc742a https://doi.org/10.1002/chin.200252172 Zobrazit plný text záznamu Plný text