Serum sclerostin values are associated with abdominal aortic calcification and predict cardiovascular events in patients with chronic kidney disease stages 3-5D
| Autor: | Liang Yuan, Jing-Jing Zhang, De-Guang Wang, Xue-Rong Wang, Li Hao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Aortography 030232 urology & nephrology 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus medicine Stage (cooking) medicine.diagnostic_test business.industry Proportional hazards model General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease carbohydrates (lipids) Endocrinology chemistry Nephrology Predictive value of tests bacteria Sclerostin business Chi-squared distribution Kidney disease |
| Zdroj: | Nephrology. 22:286-292 |
| ISSN: | 1320-5358 |
| Popis: | Aim The purpose of this study was to investigate the possible association of circulating concentrations of sclerostin with abdominal aortic calcification (AAC) and cardiovascular outcomes in patients with chronic kidney disease stage 3–5. Methods One hundred and sixty-one patients with CKD3–5D were enrolled. The patients were divided into two groups according to the presence of AAC: an AAC group (n = 99) and a non-AAC group (n = 62). The concentration of serum sclerostin was measured using an enzyme-linked immunosorbent assay (ELISA). AAC was evaluated using abdominal lateral X-ray examination. The follow-up intervals ranged from 7 to 29 months (median 16 months), and cardiovascular events (CVEs) were recorded. Results The prevalence of vascular calcification (VC) was 61.5% (99/161). Serum sclerostin was significantly higher in an AAC group than in a non-AAC group (P |
| Databáze: | OpenAIRE |
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