Reversible Inhibition of Lymphocyte-Mediated Cytolysis by Dimethyl Sulfoxide (DMSO)

Autor:	Gerald Wolberg, Kay Hiemstra, Joseph J. Burge, Robert C. Singler
Rok vydání:	1973
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 111:1435-1443
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.111.5.1435
Popis:	Dimethyl sulfoxide (DMSO) was found to inhibit reversibly in vitro lymphocyte-mediated, but not serum antibody-mediated cytolysis. Evidence is presented that the inhibition involves the prevention of productive interaction (i.e., contact which leads to lysis) and that DMSO does not inhibit the later events of the lytic cycle. Immunosuppressive activity could not be demonstrated in vivo presumably due to the inability to sustain high levels of DMSO. DMSO was used to estimate the time from interaction to lysis of target cell.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e7c5e684f656a586213cc3a75d4b8087 https://doi.org/10.4049/jimmunol.111.5.1435 Zobrazit plný text záznamu