2-(Germatran-1-yloxy)ethylamine as an inhibitor of the total activity of mononuclear alkaline phospholipase A2

Autor:	V. P. Baryshok, I. V. Zhigacheva, P. A. Storozhenko, M. M. Rasulov
Rok vydání:	2021
Předmět:	Phospholipase A Aqueous solution biology Chemistry Lipid metabolism General Chemistry Pharmacology medicine.disease Peripheral blood mononuclear cell chemistry.chemical_compound Phospholipase A2 Hyperlipidemia biology.protein medicine Animal body Ethylamine
Zdroj:	Russian Chemical Bulletin. 70:444-448
ISSN:	1573-9171 1066-5285
Popis:	The previously unknown ability of 2-(germatran-1-yloxy)ethylamine to affect the activity of alkaline phospholipase A2 was studied. Daily administration of an aqueous solution of 2-(germatran-1-yloxy)ethylamine for 2 months in an active substance dose of 10 mg per kg of animal body weight resulted in inhibition of the total activity of the alkaline phospholipase A2 of mononuclear cells. The results of the study can be used to correct the lipid metabolism in the development of hyperlipidemic disorders. This may extend the scope of applicability of the studied compound and lead to development of new pharmacological agents based on 2-(germatran-1-yloxy)ethylamine for the prevention and suppression of hyperlipidemias.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e7bc34366f755bb3c9b8fc1c1f140883 https://doi.org/10.1007/s11172-021-3106-6 Zobrazit plný text záznamu Full text from SpringerLink