Bone Mineral Density and Molecular Genetic Markers of Bone Remodeling in Blood of Cosmonauts after Long-term Missions on Board the International Space Station
| Autor: | S. A. Ponomarev, T. A. Berendeeva, S. A. Kalinin, M. P. Rykova, V. E. Novikov, G. Yu. Vassilieva, E. N. Antropova |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Bone mineral medicine.medical_specialty biology Physiology Acid phosphatase Resorption Bone remodeling 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology medicine.anatomical_structure Osteoprotegerin RANKL Physiology (medical) Internal medicine biology.protein Osteocalcin medicine 030217 neurology & neurosurgery Femoral neck |
| Zdroj: | Human Physiology. 43:686-692 |
| ISSN: | 1608-3164 0362-1197 |
| DOI: | 10.1134/s0362119717060068 |
| Popis: | The results of the investigation of the bone system of 24 Russian cosmonauts after long-term (124–199 days) missions on board the International space station (ISS) are presented. Functional adaptation of the bone system involves some complex changes in the metabolic activity of osteoblasts and osteoclasts, such as alterations of the serum concentrations of osteocalcin, tartrate-resistant acid phosphatase (TRAP), osteoprotegerin, and the activator ligand of the receptor of nuclear factor kappa-B (RANKL); in addition, in peripheral blood leucocytes, there are changes in the expression of genes regulating the development of skeletal system and bone mineral metabolism. Significant variability in the mineral density of femoral neck and molecular genetic markers studied after long-term space flights indicates individual variability of the balance of the processes of bone remodeling, bone formation and resorption. Significant bone mass losses in the femoral bone of cosmonauts are associated with more pronounced changes in the markers of metabolic activity of osteoclasts. |
| Databáze: | OpenAIRE |
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