Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality
| Autor: | José A. Almeida, Jairaj Mathur, Ye Lim Lee, Bapi Sarker, Amit Pathak |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Molecular Biology of the Cell. 34 |
| ISSN: | 1939-4586 1059-1524 |
| Popis: | Cell invasion across mechanically dissimilar environments is mediated by cell-to-matrix transfer of mechanical memory. Past mechanical priming of cells in stiff environments increases cellular forces that enhance collagen remodeling and subsequent cell invasion. Computational model explains that a positive feedback between cell and matrix memories reduces energy barrier for sustained cell invasion from stiff substrates to 3D collagen matrices. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|