Developmental and Hormonal Regulation of the Expression of Oligodendrocyte-Specific Protein/Claudin 11 in Mouse Testis1

Autor:	Mohamed Benahmed, Ali Hellani, Claire Mauduit, Catherine Deschildre, Eric Tabone, Jingwei Ji
Rok vydání:	2000
Předmět:	endocrine system medicine.medical_specialty Cell signaling Differential display urogenital system Biology Sertoli cell Endocrinology medicine.anatomical_structure Testis determining factor Internal medicine medicine Stem cell Differential display technique Claudin Spermatogenesis
Zdroj:	Endocrinology. 141:3012-3019
ISSN:	1945-7170 0013-7227
Popis:	The proliferation and differentiation of testicular progenitor stem cells into highly specialized germ cells (spermatozoa) are largely controlled by the hormonally (FSH and testosterone) regulated adjacent supporting Sertoli cells. However, the factors involved in this control remain largely unknown. In the present study, the technique of differential display PCR was used to identify target transcripts to FSH action in cultured murine Sertoli cells. Among these target transcripts, we identified the oligodendrocyte-specific protein (OSP), also known as claudin 11, which had recently been shown to play a key role in the formation of the hematotesticular barrier. Our data show that the testicular expression of OSP is dependent upon male gonad development and systemic and local signaling molecules. Indeed, OSP is expressed early in fetal development in Sertoli cells, immediately after the peak of SRY (sex-determining region, Y gene) expression, but just before that of the anti-Mullerian hormone. Postnatally, ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e7acb889acf70c17cc787d68712092df https://doi.org/10.1210/endo.141.8.7625 Zobrazit plný text záznamu