Different Regulatory Pathways of Endometrial Connexin Expression: Preimplantation Hormonal-Mediated Pathway Versus Embryo Implantation-Initiated Pathway1
| Autor: | Ruth Grümmer, Otto Traub, Kenneth S. Korach, S. W. Hewitt, Elke Winterhager |
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| Rok vydání: | 2004 |
| Předmět: |
Regulation of gene expression
medicine.medical_specialty medicine.drug_class Estrogen receptor Decidualization Connexin Cell Biology General Medicine Biology Endometrium Cell biology Endocrinology medicine.anatomical_structure Reproductive Medicine Estrogen Internal medicine otorhinolaryngologic diseases medicine sense organs Blastocyst Signal transduction |
| Zdroj: | Biology of Reproduction. 71:273-281 |
| ISSN: | 1529-7268 0006-3363 |
| DOI: | 10.1095/biolreprod.103.024067 |
| Popis: | Transformation of the endometrium into the receptive phase is under the control of ovarian steroid hormones and is modulated by embryonic signals during implantation. We have previously shown that this differentiation process is accompanied by a suppression of gap junction connexins (Cx) 26 and 43 before implantation followed by a local induction of both connexins in the implantation chamber. In the present study, we demonstrate that connexin gene expression in the rodent endometrium is regulated via two distinct signaling pathways during these different stages of early pregnancy. During preimplantation, transcription of connexins can be induced by estrogen via an estrogen receptor (ER)-dependent pathway. Additionally, Cx26 and Cx43 are induced by embryonic signals during implantation and delayed implantation as well as during artificially induced decidualization. In contrast to the estrogen-induced expression, this embryonic/decidual-associated induction of Cx26 and Cx43 could not be blocked by ... |
| Databáze: | OpenAIRE |
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