An assessment of calixarene amides as potential magnetic resonance imaging enhancement agents for gadolinium(III)

Autor:	D. Max Roundhill, Emil M. Georgiev
Rok vydání:	1997
Předmět:	medicine.diagnostic_test Gadolinium chemistry.chemical_element Magnetic resonance imaging Ligand (biochemistry) Inorganic Chemistry Nuclear magnetic resonance chemistry Stability constants of complexes In vivo Calixarene Materials Chemistry Proton NMR medicine Physical and Theoretical Chemistry
Zdroj:	Inorganica Chimica Acta. 258:93-96
ISSN:	0020-1693
DOI:	10.1016/s0020-1693(96)05489-8
Popis:	The compound 5,11,17,23-tert-butyl-25,26,27,28-carbomoyloxymethoxycalix[4]arene (1) has been evaluated as a ligand for potential use as a magnetic resonance imaging agent with gadolinium(III). The assessment procedures include high fueld relaxitivity 1H NMR measurements as well as UV-Vis stability constant measurement for the Gd(III) complex. Although the selected ligand provide to be unsuitable for in vivo applications because of the low stability constant for the complex it forms, the relaxivity value of R = 3.40(6) mM−1 s−1 is quite reasonable. These initial results however point to some future ligand modifications that are necessary in order to successfully design calixarene-based MRI enhancement agents for Gd(III).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e7894b6c5b003f3effad8dc1020859b5 https://doi.org/10.1016/s0020-1693(96)05489-8 Zobrazit plný text záznamu Full Text from ScienceDirect