Anti-inflammatory effect of Mitragyna speciosa crude methanol extract on the guinea pig ileum
| Autor: | M Taufik Hidayat, Mohamed Ali Rajion, Z. A. Zakaria, WM Shaik Mossadeq, K Syamimi, M.L. Jabit, Sulaiman, MP Azyyati, A. K. Arifah |
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| Rok vydání: | 2009 |
| Předmět: |
Stomach disorder
medicine.drug_class Mitragyna speciosa Pharmaceutical Science Bradykinin Pharmacology Anti-inflammatory Analytical Chemistry chemistry.chemical_compound In vivo Drug Discovery medicine Traditional medicine biology business.industry Stomach Organic Chemistry biology.organism_classification medicine.anatomical_structure Complementary and alternative medicine chemistry Molecular Medicine Antagonism business Histamine |
| Zdroj: | Planta Medica. 75 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0029-1234736 |
| Popis: | In a recent study, we have shown that the crude methanol extract of Mitragyna speciosa (of the family Rubiaceae) exerted significant in vivo anti-inflammatory activities in rodents as evident in the carageenan-induced paw edema and cotton pellet-induced granuloma tests [1], but the underlying mechanism is poorly understood. Our present study aims to explore the anti-inflammatory activities of this plant in vitro in order to rationalize the traditional use of this plant in the treatment of some stomach ailments [2]. The pharmacologic actions of M. speciosa were assessed by measuring the mechanical activity of isolated guinea pig ileum strips in an organ bath. The resultant methanol extract (0.01–0.05mg/ml) caused a stimulatory effect followed by a relaxation of ileal activities at a higher dose (0.3–5mg/ml) (p |
| Databáze: | OpenAIRE |
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