Porphyrazine Structures with Electron-Withdrawing Substituents as the Base for Materials for Photonics and Biomedicine
| Autor: | S. A. Lermontova, I. S. Grigor’ev, N. Yu. Shilyagina, Irina V. Balalaeva, E. Yu. Ladilina, L. G. Klapshina |
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| Rok vydání: | 2018 |
| Předmět: |
Nitrile
Chemistry General Chemical Engineering Aryl 02 engineering and technology General Chemistry Porphyrazine 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Fluorescence Combinatorial chemistry Tetrapyrrole 0104 chemical sciences Biophotonics chemistry.chemical_compound Yield (chemistry) Polar effect 0210 nano-technology |
| Zdroj: | Russian Journal of Coordination Chemistry. 44:301-315 |
| ISSN: | 1608-3318 1070-3284 |
| Popis: | A survey of the studies dealing with the development of new porphyrazine type tetrapyrrole dyes promising for the application in photonics and biophotonics is presented. An original synthetic approach to the template assembly of the porphyrazine macrocycle at room temperature in high yield has been proposed. A porphyrazine macrocycle containing eight nitrile groups at the periphery has been prepared for the first time. The replacement of four nitrile groups in the macrocycle by aryl groups has been found to generate a unique porphyrazine structure demonstrating a fluorescent molecular rotor behavior, i.e., a strong dependence of fluorescence parameters (quantum yields and lifetimes) on the viscosity of the medium. Some aspects of possible applications of the obtained compounds in biophotonics are described. Good prospects for the use of these compounds as efficient agents for tumor diagnosis, sensitizers for photodynamic therapy, and probes for intracellular viscosity are outlined. |
| Databáze: | OpenAIRE |
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