ChemInform Abstract: The Syntheses of (1R)- and (1S)-5-Methylenylcamphor and Their Epoxidation by Cytochrome P-450-CAM

Autor:	John H. Dawson, Thomas A. Bryson, Saloumeh Kadkhodayan, David M. Maryniak, George B. Crull
Rok vydání:	2010
Předmět:	Cytochrome biology Stereochemistry General Medicine biology.organism_classification Pseudomonas putida Terpene Hydroxylation Camphor chemistry.chemical_compound Stereospecificity chemistry biology.protein CYTOCHROME P 450 CAM Methylene
Zdroj:	ChemInform. 25
ISSN:	0931-7597
DOI:	10.1002/chin.199404224
Popis:	The syntheses of 1R- and 1S-5-methylenylcamphor, camphor analogues in which the two methylene hydrogens at C-5 have been replaced with an exocyclic methylene group, are described. The stereospecific epoxidations of both olefins by Pseudomonas putida cytochrome P450-CAM to give the exo -epoxides are reported. The turnover rates for the epoxidation of the 1R and 1S olefins are ten- and three-fold slower, respectively, than the rates of hydroxylation of 1R- and 1S-camphor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e777f3e54c420a9536bc343ce2cd8ea1 https://doi.org/10.1002/chin.199404224 Zobrazit plný text záznamu Plný text