Conditioned reinstatement of drug-seeking behavior with a discrete compound stimulus classically conditioned with intravenous cocaine

Autor:	Paul J. Kruzich, Kimberly M. Congelton, Ronald E. See
Rok vydání:	2001
Předmět:	Sprague dawley Behavioral Neuroscience Anesthesia Intravenous cocaine Classical conditioning Conditioning Drug seeking Stimulus (physiology) Psychology Reinforcement Drug usage Developmental psychology
Zdroj:	Behavioral Neuroscience. 115:1086-1092
ISSN:	1939-0084 0735-7044
DOI:	10.1037/0735-7044.115.5.1086
Popis:	The present study investigated the ability of a light and tone (LT) compound stimulus paired with cocaine infusions to reinstate cocaine-seeking behavior. Rats were trained to self-administer cocaine in the presence or absence of the LT during daily 3-hr sessions (maintenance). During Maintenance Days 5 and 10, rats underwent classical conditioning, whereby passive cocaine infusions were paired with either short-delayed, random, or no presentations of an LT. After extinction sessions, rats underwent test sessions in which the LT was presented in a noncontingent or response-contingent manner to measure conditioned cocaine-seeking behavior. The results demonstrated that response-contingent LT presentations significantly increased cocaine-seeking behavior and that the LT trained in a classical conditioning format transferred to an operant secondary reinforcer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e76c23f29f7a377593e720c121b51af9 https://doi.org/10.1037/0735-7044.115.5.1086 Zobrazit plný text záznamu