Studies of the enzymatic deamination of cytosine arabinoside—I

Autor:	Charles G. Smith, Gerald W. Camiener
Rok vydání:	1965
Předmět:	Pharmacology chemistry.chemical_classification Kidney Pyrimidine Deamination Cytidine Biology Biochemistry Molecular biology chemistry.chemical_compound Enzyme medicine.anatomical_structure chemistry Biotransformation medicine Distribution (pharmacology) Cytosine
Zdroj:	Biochemical Pharmacology. 14:1405-1416
ISSN:	0006-2952
DOI:	10.1016/0006-2952(65)90175-9
Popis:	Pyrimidine nucleoside deaminase activities that convert cytidine to undine, and cytosine arabinoside to uracil arabinoside, have been demonstrated in human liver and kidney. Investigations of the distribution of these enzyme activities showed marked differences among four tissues and twelve animal species tested. Preliminary studies of the properties and inhibitors of the enzymatic activity in human liver are reported. The significance of these observations and their possible chemotherapeutic applications are discussed.
Databáze:	OpenAIRE
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