High specific activity (+)-amphetamine and (+)-methamphetamine
| Autor: | Anita H. Lewin, F. Ivy Carroll, Pamela Lamb, Todd Sninski, Hunter Purdom, Charles J. McElhinny |
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| Rok vydání: | 2009 |
| Předmět: |
Stereochemistry
Chemistry Organic Chemistry Total synthesis Biological activity Methamphetamine Biochemistry Analytical Chemistry Stereospecificity Drug Discovery medicine Reductive dechlorination Radiology Nuclear Medicine and imaging Specific activity Enantiomer Amphetamine Spectroscopy medicine.drug |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 52:457-462 |
| ISSN: | 1099-1344 0362-4803 |
| DOI: | 10.1002/jlcr.1659 |
| Popis: | High specific activity (+)-amphetamine and (+)-methamphetamine were prepared by reductive dechlorination of (S)-(3′,5′-dichlorophenyl)-2-propylazide and (S)-2′6′-dichloromethamphetamine, respectively. While the latter was readily obtained by resolution of racemic 2′6′-dichloromethamphetamine using (+)-dibenzoyltartaric acid, the analogous amphetamine resisted all efforts to resolve it. Hence, the required chiral precursor was prepared by stereospecific total synthesis following methodology that had been previously developed in our Laboratories. The tritium labeled compounds had specific activity 30.1 Ci/mmol and 38.3 Ci/mmol, respectively. Copyright © 2009 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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