| Autor: | Whitcomb Kl, Kathleen Jensen-Pippo, Habberfield Alan D, DePrince Rb, Lloyd D. Ralph |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
Chemistry medicine.medical_treatment Organic Chemistry Pharmaceutical Science Enteral administration Granulocyte colony-stimulating factor Bioavailability law.invention Cytokine Pharmacokinetics Biochemistry In vivo law PEGylation medicine Recombinant DNA Molecular Medicine Pharmacology (medical) Biotechnology |
| Zdroj: | Pharmaceutical Research. 13:102-107 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1016089503186 |
| Popis: | Purpose. The focus of this paper is to demonstrate that pegylation of a therapeutic protein, recombinant human granulocyte colony stimulating factor (PEG-G-CSF), results in an increase in stability and in retention of in vivo bioactivity when administered by the intraduodenal route and may, therefore, be a suitable form of the protein for inclusion in an oral delivery formulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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