Multi-centre, randomized clinical trial on the efficacy and safety of recombinant human platelet-derived growth factor with β-tricalcium phosphate in human intra-osseous periodontal defects

Autor: Sisinty Vidyasagar, Durvasula Satyanarayana, Palaparthi Rajababu, Avula Jayakumar, Kalakonda Butchibabu, Surabhi Rohini, Sayini Pavan Kumar, Anumala Naveen, Pathakota Krishnajaneya Reddy
Rok vydání: 2010
Předmět:
Zdroj: Journal of Clinical Periodontology. 38:163-172
ISSN: 0303-6979
1600-051X
DOI: 10.1111/j.1600-051x.2010.01639.x
Popis: Jayakumar A, Rajababu P, Rohini S, Butchibabu K, Naveen A, Krishnajaneya Reddy P, Vidyasagar S, Satyanarayana D, Pavan Kumar S. Multi-centre, randomized clinical trial on efficacy and safety of recombinant human platelet-derived growth factor with β-tricalcium phosphate in human intra-osseous periodontal defects. J Clin Periodontol 2011; 38: 163–172. doi: 10.1111/j.1600-051X.2010.01639.x. Abstract Aim: The objective of the study was to evaluate the safety and efficacy of a formulation containing recombinant human platelet-derived growth factor (rhPDGF-BB) and β-tricalcium phosphate (β-TCP) in patients with periodontal defects and to compare it with those of β-TCP alone. Materials and Methods: In this double-blind, prospective, parallel, active-controlled, randomized, multi-centre clinical trial, 54 patients with periodontal osseous defects were randomly assigned to rhPDGF-BB+β-TCP or β-TCP. Following periodontal surgery, respective implantation was performed. The primary and secondary end points of treatment were evaluated at the third and the sixth month. Results: Among the outcome measures, the extent of linear bone growth (p
Databáze: OpenAIRE
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