| Autor: | L. V. Loskutova, Oleg I. Epstein, Mark B. Shtark |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty biology medicine.drug_class Peptide General Medicine S100 protein Anxiolytic General Biochemistry Genetics and Molecular Biology Tail suspension test Open field Endocrinology chemistry Internal medicine medicine biology.protein Delta sleep-inducing peptide Antibody Depression (differential diagnoses) |
| Zdroj: | Bulletin of Experimental Biology and Medicine. :20-22 |
| ISSN: | 0007-4888 |
| DOI: | 10.1023/a:1024797722719 |
| Popis: | We studied the effects of single peroral treatment with antibodies against S100 protein and delta sleep-inducing peptide in ultralow doses on behavioral characteristics of rats with anxious depression produced by acute stress (unavoidable electrical shock). Stress-produced behavioral changes and anxiolytic activity of antibodies were determined using the elevated plus-maze, open field, and tail suspension tests. High efficiency of the mixture of antibodies against S100 protein and delta sleep-inducing peptide was observed in all tests. Anxiolytic activity of anti-S100 antibodies (although less pronounced than that of the mixture of antibodies) was revealed in the elevated plus-maze and tail suspension test. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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